Homo sapiens Protein: ABI3
Summary
InnateDB Protein IDBP-380681.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ABI3
Protein Name ABI family, member 3
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000406651
InnateDB Gene IDBG-57525 (ABI3)
Protein Structure
UniProt Annotation
Function May inhibit tumor metastasis (By similarity). In vitro, reduces cell motility. {ECO:0000250, ECO:0000269PubMed:11956071}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:11956071}. Note=Colocalizes with PAK2 at leading edge of cells.
Disease Associations
Tissue Specificity Expressed in heart, lung, liver, pancreas, kidney, placenta and at low levels in brain and skeletal muscle. {ECO:0000269PubMed:10978530}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
Experimentally validated
Total 23 [view]
Protein-Protein 21 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006928 cellular component movement
GO:0030334 regulation of cell migration
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0030027 lamellipodium
Protein Structure and Domains
PDB ID
InterPro IPR001452 SH3 domain
IPR011511 Variant SH3 domain
IPR012849 Abl-interactor, homeo-domain homologous domain
PFAM PF00018
PF14604
PF07653
PF07815
PRINTS PR00452
PIRSF
SMART SM00326
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9P2A4
PhosphoSite PhosphoSite-Q9P2A4
TrEMBL
UniProt Splice Variant
Entrez Gene 51225
UniGene Hs.623236
RefSeq NP_001128658
HUGO HGNC:29859
OMIM 606363
CCDS CCDS45725
HPRD 05900
IMGT
EMBL AB037886 AC004797 AC069454 AL136709 BC007780
GenPept AAH07780 BAA90667 CAB66644