Version 5.4
Homo sapiens Protein: TIAF1
Summary
InnateDB Protein IDBP-38074.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TIAF1
Protein Name myosin XVIIIA
Synonyms MAJN; SPR210;
Species Homo sapiens
Ensembl Protein ENSP00000352424
InnateDB Gene IDBG-281602 (TIAF1)
Protein Structure
UniProt Annotation
Function Inhibits the cytotoxic effects of TNF-alpha and overexpressed TNF receptor adapters TRADD, FADD, and RIPK1. Involved in TGF-beta1 inhibition of IkappaB-alpha expression and suppression of TNF-mediated IkappaB-alpha degradation. {ECO:0000269PubMed:9918798}.
Subcellular Localization Nucleus {ECO:0000269PubMed:9918798}.
Disease Associations
Tissue Specificity Not detectable in normal kidney and liver. Up- regulated in chronic and acute allograft rejection: expressed in the inflammatory infiltrate and in tubular epithelial cells. {ECO:0000269PubMed:12829915}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
Biological Process
GO:0006915 apoptotic process
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0043066 negative regulation of apoptotic process
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O95411
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 9220
UniGene Hs.743384
RefSeq NP_004731
HUGO HGNC:11803
OMIM 609517
CCDS CCDS32599
HPRD 10268
IMGT
EMBL AC024619 AF105277 BC047669 BC058075 BC131561 CH471159
GenPept AAD04172 AAH47669 AAH58075 AAI31562 EAW51180

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca