Version 5.4
Homo sapiens Protein: DLX4
Summary
InnateDB Protein IDBP-380883.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DLX4
Protein Name distal-less homeobox 4
Synonyms BP1; DLX7; DLX8; DLX9;
Species Homo sapiens
Ensembl Protein ENSP00000410622
InnateDB Gene IDBG-57924 (DLX4)
Protein Structure
UniProt Annotation
Function May play a role in determining the production of hemoglobin S. May act as a repressor. {ECO:0000269PubMed:11909945}.
Subcellular Localization Nucleus {ECO:0000255PROSITE- ProRule:PRU00108}.
Disease Associations
Tissue Specificity Expressed in leukemia cells and placenta. Also expressed in kidney and fetal liver. {ECO:0000269PubMed:11069021, ECO:0000269PubMed:11909945}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000976 transcription regulatory region sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0007275 multicellular organismal development
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR000047 Helix-turn-helix motif
IPR001356 Homeobox domain
IPR009057 Homeodomain-like
IPR020479 Homeodomain, metazoa
PFAM PF00046
PRINTS PR00031
PR00024
PIRSF
SMART SM00389
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q92988
PhosphoSite PhosphoSite-Q92988
TrEMBL
UniProt Splice Variant
Entrez Gene 1748
UniGene Hs.591167
RefSeq NP_001925
HUGO HGNC:2917
OMIM 601911
CCDS CCDS45728
HPRD 03553
IMGT
EMBL AF028235 AF254115 AF452638 BC005812 BC014419 BC016145 BT006978 CH471109 U31762 U73328
GenPept AAC14398 AAC50942 AAC51171 AAG31975 AAH05812 AAH14419 AAH16145 AAL99503 AAP35624 EAW94651 EAW94653 EAW94654 EAW94655

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca