InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CDH13

Summary

InnateDB Protein

IDBP-381230.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CDH13

Protein Name

cadherin 13, H-cadherin (heart)

Synonyms

CDHH; P105;

Species

Homo sapiens

Ensembl Protein

ENSP00000408632

InnateDB Gene

IDBG-43918 (CDH13)

Protein Structure

UniProt Annotation

Function

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May act as a negative regulator of neural cell growth. {ECO:0000269PubMed:10737605}.

Subcellular Localization

Cell membrane; Lipid-anchor, GPI-anchor.

Disease Associations

Tissue Specificity

Highly expressed in heart. In the CNS, expressed in cerebral cortex, medulla, hippocampus, amygdala, thalamus and substantia nigra. No expression detected in cerebellum or spinal cord. {ECO:0000269PubMed:10737605, ECO:0000269PubMed:8673923}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0030169	low-density lipoprotein particle binding
GO:0045296	cadherin binding
GO:0055100	adiponectin binding
GO:0071813	lipoprotein particle binding

Biological Process

GO:0001938	positive regulation of endothelial cell proliferation
GO:0001954	positive regulation of cell-matrix adhesion
GO:0002040	sprouting angiogenesis
GO:0007156	homophilic cell adhesion
GO:0007162	negative regulation of cell adhesion
GO:0007266	Rho protein signal transduction
GO:0008285	negative regulation of cell proliferation
GO:0016339	calcium-dependent cell-cell adhesion
GO:0016601	Rac protein signal transduction
GO:0030032	lamellipodium assembly
GO:0030100	regulation of endocytosis
GO:0030335	positive regulation of cell migration
GO:0034329	cell junction assembly
GO:0034332	adherens junction organization
GO:0042058	regulation of epidermal growth factor receptor signaling pathway
GO:0043542	endothelial cell migration
GO:0043616	keratinocyte proliferation
GO:0045216	cell-cell junction organization
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048661	positive regulation of smooth muscle cell proliferation
GO:0050850	positive regulation of calcium-mediated signaling
GO:0050927	positive regulation of positive chemotaxis
GO:0051668	localization within membrane
GO:0055096	low-density lipoprotein particle mediated signaling

Cellular Component

GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005901	caveola
GO:0016020	membrane
GO:0031225	anchored component of membrane
GO:0043005	neuron projection
GO:0070062	extracellular vesicular exosome