InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BBC3

Summary

InnateDB Protein

IDBP-382425.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BBC3

Protein Name

BCL2 binding component 3

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000395862

InnateDB Gene

IDBG-59341 (BBC3)

Protein Structure

UniProt Annotation

Function

Essential mediator of p53/TP53-dependent and p53/TP53- independent apoptosis. Functions by promoting partial unfolding of BCL2L1 and dissociation of BCL2L1 from p53/TP53. Regulates ER stress-induced neuronal apoptosis. {ECO:0000269PubMed:11463391, ECO:0000269PubMed:23340338}.

Subcellular Localization

Mitochondrion {ECO:0000269PubMed:11463391, ECO:0000269PubMed:11463392, ECO:0000269PubMed:11572983}. Note=Localized to the mitochondria in order to induce cytochrome c release.

Disease Associations

Tissue Specificity

Ubiquitously expressed. {ECO:0000269PubMed:11463391}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.

Experimentally validated
Total	25 [view]
Protein-Protein	17 [view]
Protein-DNA	8 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0001836	release of cytochrome c from mitochondria
GO:0006915	apoptotic process
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006974	cellular response to DNA damage stimulus
GO:0008340	determination of adult lifespan
GO:0032464	positive regulation of protein homooligomerization
GO:0032471	negative regulation of endoplasmic reticulum calcium ion concentration
GO:0034976	response to endoplasmic reticulum stress
GO:0043525	positive regulation of neuron apoptotic process
GO:0045926	negative regulation of growth
GO:0051209	release of sequestered calcium ion into cytosol
GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0070245	positive regulation of thymocyte apoptotic process
GO:0071456	cellular response to hypoxia
GO:0090200	positive regulation of release of cytochrome c from mitochondria
GO:0097190	apoptotic signaling pathway
GO:0097193	intrinsic apoptotic signaling pathway
GO:0097194	execution phase of apoptosis
GO:1900740	positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:2001056	positive regulation of cysteine-type endopeptidase activity
GO:2001244	positive regulation of intrinsic apoptotic signaling pathway