Version 5.4
Homo sapiens Protein: CASP5
Summary
InnateDB Protein IDBP-382674.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CASP5
Protein Name caspase 5, apoptosis-related cysteine peptidase
Synonyms ICE(rel)III; ICEREL-III; ICH-3;
Species Homo sapiens
Ensembl Protein ENSP00000408455
InnateDB Gene IDBG-69591 (CASP5)
Protein Structure
UniProt Annotation
Function Mediator of programmed cell death (apoptosis).
Subcellular Localization
Disease Associations
Tissue Specificity Expressed in barely detectable amounts in most tissues except brain, highest levels being found in lung, liver and skeletal muscle.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004197 cysteine-type endopeptidase activity
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0006915 apoptotic process
GO:0021762 substantia nigra development
GO:0042981 regulation of apoptotic process
GO:0050727 regulation of inflammatory response
GO:0071260 cellular response to mechanical stimulus
GO:0097194 execution phase of apoptosis
Cellular Component
GO:0005737 cytoplasm
GO:0072558 NLRP1 inflammasome complex
Protein Structure and Domains
PDB ID
InterPro IPR001315 CARD domain
IPR011029 Death-like domain
PFAM PF00619
PRINTS
PIRSF
SMART SM00114
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P51878
PhosphoSite PhosphoSite-P51878
TrEMBL
UniProt Splice Variant
Entrez Gene 838
UniGene Hs.213327
RefSeq
HUGO HGNC:1506
OMIM 602665
CCDS
HPRD 04048
IMGT
EMBL AK296660 AP001153 BC074994 BC113406 CH471065 DQ228672 DQ228673 DQ228674 DQ228676 DQ228677 DQ508420 U28015 X94993
GenPept AAA75172 AAH74994 AAI13407 ABB58698 ABB58699 ABB58700 ABB58702 ABB58703 ABF47103 BAG59257 CAA64450 EAW67054

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca