Version 5.4
Homo sapiens Protein: ARPC1B
Summary
InnateDB Protein IDBP-382780.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARPC1B
Protein Name actin related protein 2/3 complex, subunit 1B, 41kDa
Synonyms ARC41; p40-ARC; p41-ARC;
Species Homo sapiens
Ensembl Protein ENSP00000389631
InnateDB Gene IDBG-28961 (ARPC1B)
Protein Structure
UniProt Annotation
Function Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
Subcellular Localization Cytoplasm, cytoskeleton.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 62 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 62 [view]
Protein-Protein 62 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005200 structural constituent of cytoskeleton
GO:0005515 protein binding
Biological Process
GO:0006928 cellular component movement
GO:0030833 regulation of actin filament polymerization
GO:0034314 Arp2/3 complex-mediated actin nucleation
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005885 Arp2/3 protein complex
GO:0015629 actin cytoskeleton
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR001680 WD40 repeat
IPR017383 ARP2/3 complex, 41kDa subunit (p41-arc)
IPR017986 WD40-repeat-containing domain
PFAM PF00400
PRINTS
PIRSF PIRSF038093
SMART SM00320
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O15143
PhosphoSite PhosphoSite-O15143
TrEMBL F8VXW2
UniProt Splice Variant
Entrez Gene 10095
UniGene
RefSeq XP_006715888
HUGO HGNC:704
OMIM 604223
CCDS CCDS5661
HPRD 10366
IMGT
EMBL AC004922 AF006084 AK314818 BC002562 BC002988 BC007555 CH236956 CH471091
GenPept AAB64189 AAH02562 AAH02988 AAH07555 BAG37341 EAL23882 EAW76677 EAW76678 EAW76679 EAW76680

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca