Version 5.4
Homo sapiens Protein: WNT16
Summary
InnateDB Protein IDBP-38284.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol WNT16
Protein Name wingless-type MMTV integration site family, member 16
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000222462
InnateDB Gene IDBG-38278 (WNT16)
Protein Structure
UniProt Annotation
Function Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity). {ECO:0000250}.
Subcellular Localization Secreted, extracellular space, extracellular matrix.
Disease Associations
Tissue Specificity Isoform Wnt-16b is expressed in peripheral lymphoid organs such as spleen, appendix, and lymph nodes, in kidney but not in bone marrow. Isoform Wnt-16a is expressed at significant levels only in the pancreas.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005109 frizzled binding
Biological Process
GO:0003408 optic cup formation involved in camera-type eye development
GO:0007275 multicellular organismal development
GO:0010628 positive regulation of gene expression
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016055 Wnt signaling pathway
GO:0030182 neuron differentiation
GO:0030216 keratinocyte differentiation
GO:0043616 keratinocyte proliferation
GO:0045165 cell fate commitment
GO:0046330 positive regulation of JNK cascade
GO:0046849 bone remodeling
GO:0060317 cardiac epithelial to mesenchymal transition
GO:0060548 negative regulation of cell death
GO:0090399 replicative senescence
GO:0090403 oxidative stress-induced premature senescence
Cellular Component
GO:0005576 extracellular region
GO:0005578 proteinaceous extracellular matrix
GO:0005615 extracellular space
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR005817 Wnt
IPR013304 Wnt-16 protein
PFAM PF00110
PRINTS PR01349
PR01895
PIRSF
SMART SM00097
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UBV4
PhosphoSite PhosphoSite-Q9UBV4
TrEMBL
UniProt Splice Variant
Entrez Gene 51384
UniGene Hs.272375
RefSeq NP_476509
HUGO HGNC:16267
OMIM 606267
CCDS CCDS5781
HPRD 05882
IMGT
EMBL AC006364 AF152584 AF169963 BC104919 BC104945
GenPept AAD38052 AAD49351 AAI04920 AAI04946

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca