InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CPSF4

Summary

InnateDB Protein

IDBP-382858.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CPSF4

Protein Name

cleavage and polyadenylation specific factor 4, 30kDa

Synonyms

CPSF30; NAR; NEB1;

Species

Homo sapiens

Ensembl Protein

ENSP00000395311

InnateDB Gene

IDBG-29187 (CPSF4)

Protein Structure

UniProt Annotation

Function

Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U). {ECO:0000269PubMed:14749727, ECO:0000269PubMed:9224719}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.

Experimentally validated
Total	16 [view]
Protein-Protein	16 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0008270	zinc ion binding
GO:0044822	poly(A) RNA binding
GO:0046872	metal ion binding

Biological Process

GO:0006397	mRNA processing
GO:0019048	modulation by virus of host morphology or physiology
GO:0019054	modulation by virus of host process
GO:0019058	viral life cycle
GO:0046778	modification by virus of host mRNA processing