InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: STRADA

Summary

InnateDB Protein

IDBP-382975.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

STRADA

Protein Name

STE20-related kinase adaptor alpha

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000398841

InnateDB Gene

IDBG-727185 (STRADA)

Protein Structure

UniProt Annotation

Function

Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation. {ECO:0000269PubMed:12805220, ECO:0000269PubMed:14517248, ECO:0000269PubMed:19892943}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:12805220, ECO:0000269PubMed:14517248}. Cytoplasm {ECO:0000269PubMed:12805220, ECO:0000269PubMed:14517248}.

Disease Associations

Note=A homozygous 7-kb deletion involving STRADA is a cause of a syndrome characterized by polyhydramnios, megalencephaly and symptomatic epilepsy.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019900	kinase binding
GO:0030295	protein kinase activator activity

Biological Process

GO:0006468	protein phosphorylation
GO:0006611	protein export from nucleus
GO:0007050	cell cycle arrest
GO:0008286	insulin receptor signaling pathway
GO:0032147	activation of protein kinase activity

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt