InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PRMT1

Summary

InnateDB Protein

IDBP-383387.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PRMT1

Protein Name

protein arginine methyltransferase 1

Synonyms

ANM1; HCP1; HRMT1L2; IR1B4;

Species

Homo sapiens

Ensembl Protein

ENSP00000406162

InnateDB Gene

IDBG-63299 (PRMT1)

Protein Structure

UniProt Annotation

Function

Arginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in proteins such as ESR1, histone H2, H3 and H4, PIAS1, HNRNPA1, HNRNPD, NFATC2IP, SUPT5H, TAF15 and EWS. Constitutes the main enzyme that mediates monomethylation and asymmetric dimethylation of histone H4 'Arg-4' (H4R3me1 and H4R3me2a, respectively), a specific tag for epigenetic transcriptional activation. Together with dimethylated PIAS1, represses STAT1 transcriptional activity, in the late phase of interferon gamma (IFN-gamma) signaling. May be involved in the regulation of TAF15 transcriptional activity, act as an activator of estrogen receptor (ER)-mediated transactivation, play a key role in neurite outgrowth and act as a negative regulator of megakaryocytic differentiation, by modulating p38 MAPK pathway. Methylates FOXO1 and retains it in the nucleus increasing its transcriptional activity. {ECO:0000269PubMed:11387442, ECO:0000269PubMed:11448779, ECO:0000269PubMed:12718890, ECO:0000269PubMed:18320585, ECO:0000269PubMed:18657504, ECO:0000269PubMed:18773938, ECO:0000269PubMed:19124016, ECO:0000269PubMed:19136629, ECO:0000269PubMed:19405910, ECO:0000269PubMed:20442406}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:19136629}. Nucleus, nucleoplasm {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Note=Mostly found in the cytoplasm. Colocalizes with CHTOP within the nucleus. Low levels detected also in the chromatin fraction (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Widely expressed. {ECO:0000269PubMed:11097842}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 206 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	206 [view]
Protein-Protein	201 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008168	methyltransferase activity
GO:0008170	N-methyltransferase activity
GO:0008276	protein methyltransferase activity
GO:0008469	histone-arginine N-methyltransferase activity
GO:0016274	protein-arginine N-methyltransferase activity
GO:0016275	[cytochrome c]-arginine N-methyltransferase activity
GO:0016740	transferase activity
GO:0030519	snoRNP binding
GO:0035241	protein-arginine omega-N monomethyltransferase activity
GO:0035242	protein-arginine omega-N asymmetric methyltransferase activity
GO:0042054	histone methyltransferase activity
GO:0042802	identical protein binding
GO:0044020	histone methyltransferase activity (H4-R3 specific)
GO:0044822	poly(A) RNA binding

Biological Process

GO:0001701	in utero embryonic development
GO:0006355	regulation of transcription, DNA-templated
GO:0006479	protein methylation
GO:0007166	cell surface receptor signaling pathway
GO:0008152	metabolic process
GO:0016571	histone methylation
GO:0018216	peptidyl-arginine methylation
GO:0019919	peptidyl-arginine methylation, to asymmetrical-dimethyl arginine
GO:0031175	neuron projection development
GO:0035247	peptidyl-arginine omega-N-methylation
GO:0043985	histone H4-R3 methylation
GO:0045087	innate immune response (InnateDB)
GO:0045653	negative regulation of megakaryocyte differentiation

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0043234	protein complex

Protein Structure and Domains

PDB ID

InterPro

IPR003402 tRNA transferase Trm5/Tyw2
IPR007848 Methyltransferase small domain
IPR010456 Ribosomal L11 methyltransferase, PrmA
IPR013216 Methyltransferase type 11
IPR025799 Protein arginine N-methyltransferase
IPR029063 S-adenosyl-L-methionine-dependent methyltransferase-like

PFAM

PF02475
PF05175
PF06325
PF08241
PF05185

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-Q99873