Version 5.4
Homo sapiens Protein: RPH3A
Summary
InnateDB Protein IDBP-383584.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RPH3A
Protein Name rabphilin 3A homolog (mouse)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000405357
InnateDB Gene IDBG-58175 (RPH3A)
Protein Structure
UniProt Annotation
Function Protein transport. Probably involved with Ras-related protein Rab-3A in synaptic vesicle traffic and/or synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal (By similarity). {ECO:0000250}.
Subcellular Localization Cell junction, synapse {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 17 [view]
Protein-Protein 17 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005544 calcium-dependent phospholipid binding
GO:0017137 Rab GTPase binding
GO:0046872 metal ion binding
Biological Process
GO:0006886 intracellular protein transport
Cellular Component
GO:0008021 synaptic vesicle
GO:0016020 membrane
GO:0030054 cell junction
Protein Structure and Domains
PDB ID
InterPro IPR000008 C2 domain
IPR001565 Synaptotagmin
IPR010911 Zinc finger, FYVE-type
IPR011011 Zinc finger, FYVE/PHD-type
IPR017455 Zinc finger, FYVE-related
PFAM PF00168
PF02318
PRINTS PR00360
PR00399
PIRSF
SMART SM00239
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Y2J0
PhosphoSite PhosphoSite-Q9Y2J0
TrEMBL F8W1K7
UniProt Splice Variant
Entrez Gene 22895
UniGene Hs.21239
RefSeq
HUGO HGNC:17056
OMIM 612159
CCDS CCDS44979
HPRD 15273
IMGT
EMBL AB023202 AC004104 AC004216 AC004465 AC004551 AC007425 AK295696 BC017259 CH471054
GenPept AAH17259 BAA76829 BAH12159 EAW98017 EAW98018

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca