Version 5.4
Homo sapiens Protein: ARSG
Summary
InnateDB Protein IDBP-383703.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARSG
Protein Name arylsulfatase G
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000407193
InnateDB Gene IDBG-65797 (ARSG)
Protein Structure
UniProt Annotation
Function Displays arylsulfatase activity at acidic pH with pseudosubstrates, such as p-nitrocatechol sulfate and also, but with lower activity, p-nitrophenyl sulfate and 4- methylumbelliferyl sulfate. {ECO:0000269PubMed:18283100}.
Subcellular Localization Lysosome {ECO:0000269PubMed:12461688, ECO:0000269PubMed:18283100}. Note=Previously observed endoplasmic reticulum localization is most likely due to folding/maturation problems for overexpressed proteins.
Disease Associations
Tissue Specificity Widely expressed, with very low expression in brain, lung, heart and skeletal muscle. {ECO:0000269PubMed:12461688, ECO:0000269PubMed:18283100}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004065 arylsulfatase activity
GO:0008484 sulfuric ester hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0006665 sphingolipid metabolic process
GO:0006687 glycosphingolipid metabolic process
GO:0006790 sulfur compound metabolic process
GO:0008152 metabolic process
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005615 extracellular space
GO:0005764 lysosome
GO:0005783 endoplasmic reticulum
GO:0005788 endoplasmic reticulum lumen
Protein Structure and Domains
PDB ID
InterPro IPR000917 Sulfatase
IPR017850 Alkaline-phosphatase-like, core domain
PFAM PF00884
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96EG1
PhosphoSite PhosphoSite-Q96EG1
TrEMBL J9JIG6
UniProt Splice Variant
Entrez Gene 22901
UniGene Hs.605017
RefSeq NP_055775
HUGO HGNC:24102
OMIM 610008
CCDS CCDS11676
HPRD 13826
IMGT
EMBL AB023218 AC005332 AC007780 AY358380 BC012375 CH471099
GenPept AAH12375 AAQ88746 BAA76845 EAW89055 EAW89056

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca