Version 5.4
Homo sapiens Protein: COMMD6
Summary
InnateDB Protein IDBP-38391.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol COMMD6
Protein Name COMM domain containing 6
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000348054
InnateDB Gene IDBG-38385 (COMMD6)
Protein Structure
UniProt Annotation
Function Down-regulates activation of NF-kappa-B. Inhibits TNF- induced NFKB1 activation. {ECO:0000269PubMed:15799966, ECO:0000269PubMed:16573520}.
Subcellular Localization Nucleus {ECO:0000269PubMed:16573520}. Cytoplasm {ECO:0000269PubMed:16573520}.
Disease Associations
Tissue Specificity Ubiquitous. Expressed in brain, heart, skeletal muscle, lung, pancreas, liver, kidney, small intestine and placenta. {ECO:0000269PubMed:15799966, ECO:0000269PubMed:16573520}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0051059 NF-kappaB binding
Biological Process
GO:0032088 negative regulation of NF-kappaB transcription factor activity
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR009886 HCaRG
PFAM PF07258
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q7Z4G1
PhosphoSite PhosphoSite-Q7Z4G1
TrEMBL
UniProt Splice Variant
Entrez Gene 170622
UniGene Hs.713055
RefSeq NP_987093
HUGO HGNC:24015
OMIM 612377
CCDS CCDS9452
HPRD 13084
IMGT
EMBL AF169971 AL137244 AY542161 BC117391 BC143912 BC171758
GenPept AAI17392 AAI43913 AAI71758 AAQ13599 AAS22243 CAI12417 CAQ09795

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca