Version 5.4
Homo sapiens Protein: TNFAIP8
Summary
InnateDB Protein IDBP-38404.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TNFAIP8
Protein Name tumor necrosis factor, alpha-induced protein 8
Synonyms GG2-1; MDC-3.13; NDED; SCC-S2; SCCS2;
Species Homo sapiens
Ensembl Protein ENSP00000274456
InnateDB Gene IDBG-38402 (TNFAIP8)
Protein Structure
UniProt Annotation
Function Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation. {ECO:0000269PubMed:10644768, ECO:0000269PubMed:11346652, ECO:0000269PubMed:14724590}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:14724590}.
Disease Associations
Tissue Specificity Expressed at high levels in the spleen, lymph node, thymus, thyroid, bone marrow and placenta. Expressed at high levels both in various tumor tissues, unstimulated and cytokine- activated cultured cells. Expressed at low levels in the spinal cord, ovary, lung, adrenal glands, heart, brain, testis and skeletal muscle. {ECO:0000269PubMed:10233894, ECO:0000269PubMed:10644768, ECO:0000269PubMed:14724590}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 15 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process
Biological Process
GO:0043066 negative regulation of apoptotic process
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
Cellular Component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR008477 Protein of unknown function DUF758
PFAM PF05527
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O95379
PhosphoSite PhosphoSite-
TrEMBL E5RIJ3
UniProt Splice Variant
Entrez Gene 25816
UniGene Hs.656274
RefSeq NP_001273746
HUGO HGNC:17260
OMIM 612111
CCDS CCDS47257
HPRD 18204
IMGT
EMBL AC008475 AC027320 AC035144 AF070671 AF098933 AF099935 AF099936 AK001850 AK001931 AK301281 BC005352 BC007014 CH471086 CR457137
GenPept AAC72975 AAC72976 AAC83229 AAF29435 AAH05352 AAH07014 BAG50983 BAG50994 BAH13449 CAG33418 EAW48914

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca