InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PXN

Summary

InnateDB Protein

IDBP-384133.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PXN

Protein Name

paxillin

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000395536

InnateDB Gene

IDBG-60317 (PXN)

Protein Structure

UniProt Annotation

Function

Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion).

Subcellular Localization

Cytoplasm, cytoskeleton {ECO:0000269PubMed:20489202}. Cell junction, focal adhesion {ECO:0000269PubMed:20489202}. Cytoplasm, cell cortex {ECO:0000250}. Note=Colocalizes with integrins at the cell periphery. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 236 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.

Experimentally validated
Total	236 [view]
Protein-Protein	236 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	23 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008013	beta-catenin binding
GO:0008270	zinc ion binding
GO:0017166	vinculin binding

Biological Process

GO:0006936	muscle contraction
GO:0007155	cell adhesion
GO:0007165	signal transduction
GO:0007172	signal complex assembly
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0034329	cell junction assembly
GO:0034614	cellular response to reactive oxygen species
GO:0060396	growth hormone receptor signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0005875	microtubule associated complex
GO:0005886	plasma membrane
GO:0005925	focal adhesion
GO:0005938	cell cortex
GO:0030027	lamellipodium