InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TBRG1

Summary

InnateDB Protein

IDBP-384298.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TBRG1

Protein Name

transforming growth factor beta regulator 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000409016

InnateDB Gene

IDBG-75180 (TBRG1)

Protein Structure

UniProt Annotation

Function

Acts as a growth inhibitor. Can activate p53/TP53, causes G1 arrest and collaborates with CDKN2A to restrict proliferation, but does not require either protein to inhibit DNA synthesis. Redistributes CDKN2A into the nucleoplasm. Involved in maintaining chromosomal stability. {ECO:0000269PubMed:17110379}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:17110379}.

Disease Associations

Tissue Specificity

Widely expressed at low levels in most tissues, with highest levels in pancreas, lung and liver. Expression is decreased in primary tumors including lung, liver, breast, pancreas and kidney carcinomas, chronic lymphocytic leukemia and diffuse large B-cell lymphoma. {ECO:0000269PubMed:17110379}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	2 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006260	DNA replication
GO:0007050	cell cycle arrest
GO:0008285	negative regulation of cell proliferation
GO:0032066	nucleolus to nucleoplasm transport
GO:0050821	protein stabilization