Version 5.4
Homo sapiens Protein: ERLIN1
Summary
InnateDB Protein IDBP-384334.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ERLIN1
Protein Name ER lipid raft associated 1
Synonyms C10orf69; Erlin-1; KE04; KEO4; SPFH1; SPG62;
Species Homo sapiens
Ensembl Protein ENSP00000410964
InnateDB Gene IDBG-86258 (ERLIN1)
Protein Structure
UniProt Annotation
Function Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). {ECO:0000269PubMed:19240031}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000269PubMed:11118313, ECO:0000269PubMed:16835267, ECO:0000269PubMed:19240031}; Single-pass type II membrane protein {ECO:0000269PubMed:11118313, ECO:0000269PubMed:16835267, ECO:0000269PubMed:19240031}. Note=Associated with lipid raft-like domains of the endoplasmic reticulum membrane.
Disease Associations
Tissue Specificity Expressed in heart, placenta, liver, kidney, pancreas, prostate, testis, ovary and small intestine. {ECO:0000269PubMed:11118313}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
Experimentally validated
Total 25 [view]
Protein-Protein 23 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0030433 ER-associated ubiquitin-dependent protein catabolic process
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
GO:0043234 protein complex
Protein Structure and Domains
PDB ID
InterPro IPR001107 Band 7 protein
PFAM PF01145
PRINTS
PIRSF
SMART SM00244
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O75477
PhosphoSite PhosphoSite-O75477
TrEMBL D3DR65
UniProt Splice Variant
Entrez Gene 10613
UniGene Hs.595526
RefSeq NP_006450
HUGO HGNC:16947
OMIM 611604
CCDS CCDS7487
HPRD 08502
IMGT
EMBL AF064093 AK222480 AL138921 BC031791 CH471066
GenPept AAC26658 AAH31791 BAD96200 CAQ10515 EAW49846 EAW49847

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca