InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MBOAT7

Summary

InnateDB Protein

IDBP-384618.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MBOAT7

Protein Name

membrane bound O-acyltransferase domain containing 7

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000410503

InnateDB Gene

IDBG-68251 (MBOAT7)

Protein Structure

UniProt Annotation

Function

Acyltransferase which mediates the conversion of lysophosphatidylinositol (1-acylglycerophosphatidylinositol or LPI) into phosphatidylinositol (1,2-diacyl-sn-glycero-3- phosphoinositol or PI) (LPIAT activity). Prefers arachidonoyl-CoA as the acyl donor. Lysophospholipid acyltransferases (LPLATs) catalyze the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle. {ECO:0000269PubMed:18094042, ECO:0000269PubMed:18772128}.

Subcellular Localization

Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Overexpressed in metastatic breast and bladder carcinomas relative to normal breast epithelium and urothelium. {ECO:0000269PubMed:18772128}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.

Experimentally validated
Total	14 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0016747	transferase activity, transferring acyl groups other than amino-acyl groups

Biological Process

GO:0006644	phospholipid metabolic process
GO:0036149	phosphatidylinositol acyl-chain remodeling
GO:0044281	small molecule metabolic process
GO:0046474	glycerophospholipid biosynthetic process