Version 5.4
Homo sapiens Protein: HCAR1
Summary
InnateDB Protein IDBP-384671.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HCAR1
Protein Name hydroxycarboxylic acid receptor 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000389255
InnateDB Gene IDBG-62781 (HCAR1)
Protein Structure
UniProt Annotation
Function Acts as a receptor for L-lactate and mediates its anti- lipolytic effect through a G(i)-protein-mediated pathway. {ECO:0000269PubMed:19047060}.
Subcellular Localization Cell membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity Expressed abundantly in brown and white fat. It also detectable at lower levels in liver, kidney, skeletal muscle, brain and pituitary. Not detected in frontal, temporal and occipital lobes of the cortex, basal forebrain, caudate nucleus, nucleus accumbens and hippocampus. {ECO:0000269PubMed:11574155, ECO:0000269PubMed:19047060}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0032355 response to estradiol
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
IPR017452 GPCR, rhodopsin-like, 7TM
PFAM PF00001
PRINTS PR00237
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BXC0
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 27198
UniGene Hs.711001
RefSeq NP_115943
HUGO HGNC:4532
OMIM 606923
CCDS CCDS9236
HPRD 06083
IMGT
EMBL AB065866 AB083631 AC026333 AF345568 AF411110 AK313955 AY507143 BC066881 BC066882 BC066883 BC067484 BC095506 CH471054 DQ157221 EU809458
GenPept AAH66881 AAH66882 AAH66883 AAH67484 AAH95506 AAK29071 AAL26481 AAR92485 AAZ67915 ACJ03844 BAB89344 BAC06084 BAG36671 EAW98337

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca