Version 5.4
Homo sapiens Protein: ARL6IP4
Summary
InnateDB Protein IDBP-384754.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARL6IP4
Protein Name ADP-ribosylation-like factor 6 interacting protein 4
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000414847
InnateDB Gene IDBG-63187 (ARL6IP4)
Protein Structure
UniProt Annotation
Function Involved in modulating alternative pre-mRNA splicing with either 5' distal site activation or preferential use of 3' proximal site. In case of infection by Herpes simplex virus (HSVI), may act as a splicing inhibitor of HSVI pre-mRNA. {ECO:0000269PubMed:19582790}.
Subcellular Localization Nucleus, nucleolus {ECO:0000269PubMed:19582790}. Nucleus speckle {ECO:0000269PubMed:19582790}.
Disease Associations
Tissue Specificity Isoforms 3 and 7 were identified in brain, pancreas, prostate, and testis, but little or no message could be detected in other tissues. {ECO:0000269PubMed:19582790}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 11 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006397 mRNA processing
GO:0008380 RNA splicing
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0016607 nuclear speck
Protein Structure and Domains
PDB ID
InterPro IPR019532 Nuclear RNA-splicing-associated protein, SR-25
PFAM PF10500
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q66PJ3
PhosphoSite PhosphoSite-Q66PJ3
TrEMBL F8WCT1
UniProt Splice Variant
Entrez Gene 51329
UniGene
RefSeq NP_001265307
HUGO HGNC:18076
OMIM 607668
CCDS CCDS45004
HPRD 09640
IMGT
EMBL AB035384 AC026362 AF267748 BC001958 BC015569 BC015909 BC094839 CH471054 DQ099385 EF036485 EU624490 EU624491
GenPept AAF76892 AAH01958 AAH15569 AAH15909 AAH94839 AAZ13761 ABO65071 ACF07995 ACF07996 BAA94744 EAW98374 EAW98376

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca