InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LDB1

Summary

InnateDB Protein

IDBP-384825.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LDB1

Protein Name

LIM domain binding 1

Synonyms

CLIM2; NLI;

Species

Homo sapiens

Ensembl Protein

ENSP00000392466

InnateDB Gene

IDBG-87759 (LDB1)

Protein Structure

UniProt Annotation

Function

Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors. May regulate the transcriptional activity of LIM-containing proteins by determining specific partner interactions. Plays a role in the development of interneurons and motor neurons in cooperation with LHX3 and ISL1. Acts synergistically with LHX1/LIM1 in axis formation and activation of gene expression. Acts with LMO2 in the regulation of red blood cell development, maintaining erythroid precursors in an immature state (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Expressed in a wide range of adult tissues including brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, small intestine, lung and peripheral blood leukocytes. {ECO:0000269PubMed:16815859}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 46 interaction(s) predicted by orthology.

Experimentally validated
Total	32 [view]
Protein-Protein	31 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	46 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000989	transcription factor binding transcription factor activity
GO:0001102	RNA polymerase II activating transcription factor binding
GO:0001158	enhancer sequence-specific DNA binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0019899	enzyme binding
GO:0030274	LIM domain binding
GO:0042803	protein homodimerization activity
GO:0043621	protein self-association

Biological Process

GO:0000972	transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery
GO:0001702	gastrulation with mouth forming second
GO:0001942	hair follicle development
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0007275	multicellular organismal development
GO:0009948	anterior/posterior axis specification
GO:0010669	epithelial structure maintenance
GO:0016055	Wnt signaling pathway
GO:0021549	cerebellum development
GO:0021702	cerebellar Purkinje cell differentiation
GO:0022607	cellular component assembly
GO:0030182	neuron differentiation
GO:0032784	regulation of DNA-templated transcription, elongation
GO:0035019	somatic stem cell maintenance
GO:0043973	histone H3-K4 acetylation
GO:0045647	negative regulation of erythrocyte differentiation
GO:0045785	positive regulation of cell adhesion
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046985	positive regulation of hemoglobin biosynthetic process
GO:0060322	head development