InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PFN2

Summary

InnateDB Protein

IDBP-384840.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PFN2

Protein Name

profilin 2

Synonyms

D3S1319E; PFL;

Species

Homo sapiens

Ensembl Protein

ENSP00000410464

InnateDB Gene

IDBG-60946 (PFN2)

Protein Structure

UniProt Annotation

Function

Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG.

Subcellular Localization

Cytoplasm, cytoskeleton.

Disease Associations

Tissue Specificity

Highly expressed in brain, skeletal muscle and kidney and less strongly in heart, placenta, lung and liver.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	39 [view]
Protein-Protein	39 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000774	adenyl-nucleotide exchange factor activity
GO:0003779	actin binding
GO:0003785	actin monomer binding
GO:0005515	protein binding
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding

Biological Process

GO:0010633	negative regulation of epithelial cell migration
GO:0030036	actin cytoskeleton organization
GO:0030837	negative regulation of actin filament polymerization
GO:0030838	positive regulation of actin filament polymerization
GO:0032233	positive regulation of actin filament bundle assembly
GO:0032781	positive regulation of ATPase activity
GO:0033138	positive regulation of peptidyl-serine phosphorylation
GO:0051496	positive regulation of stress fiber assembly
GO:1900028	negative regulation of ruffle assembly