InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: EPN1

Summary

InnateDB Protein

IDBP-385468.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EPN1

Protein Name

epsin 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000406209

InnateDB Gene

IDBG-71084 (EPN1)

Protein Structure

UniProt Annotation

Function

Binds to membranes enriched in phosphatidylinositol 4,5- bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (By similarity). Regulates receptor-mediated endocytosis. {ECO:0000250, ECO:0000269PubMed:10557078}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Nucleus {ECO:0000250}. Membrane, clathrin-coated pit {ECO:0000250}. Note=Associated with the cytoplasmic membrane at sites where clathrin-coated pits are forming. Colocalizes with clathrin and AP-2 in a punctate pattern on the plasma membrane. Detected in presynaptic nerve terminals and in Golgi stacks. May shuttle to the nucleus when associated with ZBTB16/ZNF145 (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 52 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	52 [view]
Protein-Protein	52 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005543	phospholipid binding
GO:0008134	transcription factor binding
GO:0008289	lipid binding

Biological Process

GO:0001701	in utero embryonic development
GO:0006897	endocytosis
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007219	Notch signaling pathway
GO:0007565	female pregnancy
GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway
GO:0048568	embryonic organ development

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005905	coated pit

Protein Structure and Domains

PDB ID

InterPro

IPR001026 Epsin domain, N-terminal
IPR003903 Ubiquitin interacting motif
IPR008942 ENTH/VHS
IPR011417 AP180 N-terminal homology (ANTH) domain
IPR013809 Epsin-like, N-terminal

PFAM

PF01417
PF02809
PF07651

PRINTS

PIRSF

SMART

SM00726
SM00273

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9Y6I3