Version 5.4
Homo sapiens Protein: KCNMB2
Summary
InnateDB Protein IDBP-385562.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KCNMB2
Protein Name potassium large conductance calcium-activated channel, subfamily M, beta member 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000397483
InnateDB Gene IDBG-65972 (KCNMB2)
Protein Structure
UniProt Annotation
Function Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Acts as a negative regulator that confers rapid and complete inactivation of KCNMA1 channel complex. May participate in KCNMA1 inactivation in chromaffin cells of the adrenal gland or in hippocampal CA1 neurons. {ECO:0000269PubMed:10097176, ECO:0000269PubMed:10377337}.
Subcellular Localization Membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity Expressed in kidney, heart and brain. Highly expressed in ovary. Expressed at low level in other tissues. {ECO:0000269PubMed:10097176, ECO:0000269PubMed:10377337, ECO:0000269PubMed:10692449}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008200 ion channel inhibitor activity
GO:0015269 calcium-activated potassium channel activity
GO:0015459 potassium channel regulator activity
Biological Process
GO:0001508 action potential
GO:0005513 detection of calcium ion
GO:0006813 potassium ion transport
GO:0007268 synaptic transmission
GO:0007596 blood coagulation
GO:0019228 neuronal action potential
GO:0019229 regulation of vasoconstriction
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0008076 voltage-gated potassium channel complex
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR003930 Potassium channel, calcium-activated, BK, beta subunit
IPR015382 KCNMB2, ball/chain domain
PFAM PF03185
PF09303
PRINTS PR01450
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Y691
PhosphoSite PhosphoSite-Q9Y691
TrEMBL E7ETM2
UniProt Splice Variant
Entrez Gene 10242
UniGene Hs.478368
RefSeq NP_852006
HUGO HGNC:6286
OMIM 605214
CCDS CCDS3223
HPRD 05557
IMGT
EMBL AC024220 AC092929 AC109779 AC117457 AC139661 AF099137 AF209747 AK298291 BC017825
GenPept AAD23380 AAF36562 AAH17825 BAH12749

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca