InnateDB Protein
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IDBP-385564.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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KCNMB2
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Protein Name
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potassium large conductance calcium-activated channel, subfamily M, beta member 2
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000407592
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InnateDB Gene
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IDBG-65972 (KCNMB2)
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Protein Structure
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Function |
Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Acts as a negative regulator that confers rapid and complete inactivation of KCNMA1 channel complex. May participate in KCNMA1 inactivation in chromaffin cells of the adrenal gland or in hippocampal CA1 neurons. {ECO:0000269PubMed:10097176, ECO:0000269PubMed:10377337}.
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Subcellular Localization |
Membrane; Multi-pass membrane protein.
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Disease Associations |
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Tissue Specificity |
Expressed in kidney, heart and brain. Highly expressed in ovary. Expressed at low level in other tissues. {ECO:0000269PubMed:10097176, ECO:0000269PubMed:10377337, ECO:0000269PubMed:10692449}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0008200
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ion channel inhibitor activity
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GO:0015269
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calcium-activated potassium channel activity
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GO:0015459
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potassium channel regulator activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR003930
Potassium channel, calcium-activated, BK, beta subunit
IPR015382
KCNMB2, ball/chain domain
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PFAM |
PF03185
PF09303
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PRINTS |
PR01450
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9Y691
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PhosphoSite |
PhosphoSite-Q9Y691
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TrEMBL |
E7ETM2
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UniProt Splice Variant |
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Entrez Gene |
10242
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UniGene |
Hs.478368
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RefSeq |
NP_005823
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HUGO |
HGNC:6286
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OMIM |
605214
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CCDS |
CCDS3223
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HPRD |
05557
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IMGT |
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EMBL |
AC024220
AC092929
AC109779
AC117457
AC139661
AF099137
AF209747
AK298291
BC017825
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GenPept |
AAD23380
AAF36562
AAH17825
BAH12749
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