Version 5.4
Homo sapiens Protein: ZMAT3
Summary
InnateDB Protein IDBP-385581.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ZMAT3
Protein Name zinc finger, matrin-type 3
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000396506
InnateDB Gene IDBG-65982 (ZMAT3)
Protein Structure
UniProt Annotation
Function Acts as a bona fide target gene of p53/TP53. May play a role in the TP53-dependent growth regulatory pathway. May contribute to TP53-mediated apoptosis by regulation of TP53 expression and translocation to the nucleus and nucleolus. {ECO:0000269PubMed:11571644}.
Subcellular Localization Nucleus {ECO:0000269PubMed:11571644}. Nucleus, nucleolus {ECO:0000269PubMed:11571644}.
Disease Associations
Tissue Specificity Highly expressed in adult brain, and moderately in adult kidney and testis. Not detected in fetal brain, heart, pancreas, adrenal gland, liver or small intestine. {ECO:0000269PubMed:11689294}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006915 apoptotic process
GO:0006974 cellular response to DNA damage stimulus
GO:0015031 protein transport
GO:0040008 regulation of growth
Cellular Component
GO:0005730 nucleolus
Protein Structure and Domains
PDB ID
InterPro IPR003604 Zinc finger, U1-type
IPR015880 Zinc finger, C2H2-like
IPR022755 Zinc finger, double-stranded RNA binding
PFAM PF12171
PRINTS
PIRSF
SMART SM00451
SM00355
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9HA38
PhosphoSite PhosphoSite-Q9HA38
TrEMBL C9J8H5
UniProt Splice Variant
Entrez Gene 64393
UniGene Hs.611263
RefSeq NP_689426
HUGO HGNC:29983
OMIM 606452
CCDS CCDS46962
HPRD 07343
IMGT
EMBL AC117456 AF355465 AK022358 AK122768 AY037945 BC002896 CH471052
GenPept AAH02896 AAK71491 AAK83287 BAB14020 BAG53718 EAW78424 EAW78425 EAW78426

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca