InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CDC7

Summary

InnateDB Protein

IDBP-386681.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CDC7

Protein Name

cell division cycle 7 homolog (S. cerevisiae)

Synonyms

CDC7L1; HsCDC7; Hsk1; huCDC7;

Species

Homo sapiens

Ensembl Protein

ENSP00000393139

InnateDB Gene

IDBG-100234 (CDC7)

Protein Structure

UniProt Annotation

Function

Seems to phosphorylate critical substrates that regulate the G1/S phase transition and/or DNA replication. Can phosphorylates MCM2 and MCM3. {ECO:0000269PubMed:12065429}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	44 [view]
Protein-Protein	39 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0046872	metal ion binding

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0006260	DNA replication
GO:0006468	protein phosphorylation
GO:0008284	positive regulation of cell proliferation
GO:0010571	positive regulation of nuclear cell cycle DNA replication
GO:0010971	positive regulation of G2/M transition of mitotic cell cycle
GO:0044770	cell cycle phase transition
GO:0051301	cell division

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0015630	microtubule cytoskeleton
GO:0045171	intercellular bridge

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt