InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CTBP2

Summary

InnateDB Protein

IDBP-386713.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CTBP2

Protein Name

C-terminal binding protein 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000410474

InnateDB Gene

IDBG-92761 (CTBP2)

Protein Structure

UniProt Annotation

Function

Corepressor targeting diverse transcription regulators. Functions in brown adipose tissue (BAT) differentiation (By similarity). {ECO:0000250}.Isoform 2 probably acts as a scaffold for specialized synapses.

Subcellular Localization

Nucleus {ECO:0000305}. Cell junction, synapse {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitous. Highest levels in heart, skeletal muscle, and pancreas.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 98 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Experimentally validated
Total	98 [view]
Protein-Protein	98 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0051287	NAD binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0008152	metabolic process
GO:0008285	negative regulation of cell proliferation
GO:0019079	viral genome replication
GO:0045892	negative regulation of transcription, DNA-templated
GO:0050872	white fat cell differentiation
GO:0055114	oxidation-reduction process