InnateDB Protein
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IDBP-387320.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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DHRS9
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Protein Name
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dehydrogenase/reductase (SDR family) member 9
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Synonyms
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3-alpha-HSD; 3ALPHA-HSD; RDH-E2; RDH-TBE; RDH15; RDHL; RDHTBE; RETSDR8; SDR9C4;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000388564
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InnateDB Gene
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IDBG-74381 (DHRS9)
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Protein Structure
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Function |
3-alpha-hydroxysteroid dehydrogenase that converts 3- alpha-tetrahydroprogesterone (allopregnanolone) to dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone. May play a role in the biosynthesis of retinoic acid from retinaldehyde, but seems to have low activity with retinoids. Can utilize both NADH and NADPH. {ECO:0000269PubMed:11294878, ECO:0000269PubMed:11304534, ECO:0000269PubMed:12618084}.
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Subcellular Localization |
Microsome membrane {ECO:0000269PubMed:11294878, ECO:0000269PubMed:11304534, ECO:0000269PubMed:12618084}. Endoplasmic reticulum membrane {ECO:0000305}. Note=Associated with microsomal membranes.
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Disease Associations |
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Tissue Specificity |
Highly expressed in trachea and epidermis. Detected at lower levels in spinal cord, bone marrow, brain, tongue, esophagus, heart, colon, testis, placenta, lung, skeletal muscle and lymph node. {ECO:0000269PubMed:11294878, ECO:0000269PubMed:11304534, ECO:0000269PubMed:12618084}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
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Biological Process |
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Cellular Component |
GO:0030176
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integral component of endoplasmic reticulum membrane
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PDB ID |
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InterPro |
IPR002198
Short-chain dehydrogenase/reductase SDR
IPR002347
Glucose/ribitol dehydrogenase
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PFAM |
PF00106
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PRINTS |
PR00080
PR00081
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PIRSF |
PIRSF000126
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9BPW9
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PhosphoSite |
PhosphoSite-
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TrEMBL |
Q53TL1
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UniProt Splice Variant |
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Entrez Gene |
10170
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UniGene |
Hs.608963
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RefSeq |
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HUGO |
HGNC:16888
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OMIM |
612131
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CCDS |
CCDS2231
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HPRD |
09916
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IMGT |
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EMBL |
AC007556
AC008177
AF240697
AF240698
AF295380
AF343729
AF529286
AF529287
AF529288
AK296625
AY017349
AY359046
BC058883
CH471058
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GenPept |
AAF82747
AAF82748
AAG49422
AAH58883
AAK37528
AAL37037
AAN04008
AAN04009
AAN04010
AAQ89405
AAX88964
AAY24306
BAH12402
EAX11282
EAX11283
EAX11284
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