Version 5.4
Homo sapiens Protein: DHRS9
Summary
InnateDB Protein IDBP-387323.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DHRS9
Protein Name dehydrogenase/reductase (SDR family) member 9
Synonyms 3-alpha-HSD; 3ALPHA-HSD; RDH-E2; RDH-TBE; RDH15; RDHL; RDHTBE; RETSDR8; SDR9C4;
Species Homo sapiens
Ensembl Protein ENSP00000388066
InnateDB Gene IDBG-74381 (DHRS9)
Protein Structure
UniProt Annotation
Function 3-alpha-hydroxysteroid dehydrogenase that converts 3- alpha-tetrahydroprogesterone (allopregnanolone) to dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone. May play a role in the biosynthesis of retinoic acid from retinaldehyde, but seems to have low activity with retinoids. Can utilize both NADH and NADPH. {ECO:0000269PubMed:11294878, ECO:0000269PubMed:11304534, ECO:0000269PubMed:12618084}.
Subcellular Localization Microsome membrane {ECO:0000269PubMed:11294878, ECO:0000269PubMed:11304534, ECO:0000269PubMed:12618084}. Endoplasmic reticulum membrane {ECO:0000305}. Note=Associated with microsomal membranes.
Disease Associations
Tissue Specificity Highly expressed in trachea and epidermis. Detected at lower levels in spinal cord, bone marrow, brain, tongue, esophagus, heart, colon, testis, placenta, lung, skeletal muscle and lymph node. {ECO:0000269PubMed:11294878, ECO:0000269PubMed:11304534, ECO:0000269PubMed:12618084}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004022 alcohol dehydrogenase (NAD) activity
GO:0004745 retinol dehydrogenase activity
GO:0016854 racemase and epimerase activity
GO:0047035 testosterone dehydrogenase (NAD+) activity
Biological Process
GO:0008209 androgen metabolic process
GO:0030855 epithelial cell differentiation
GO:0042448 progesterone metabolic process
GO:0042572 retinol metabolic process
GO:0042904 9-cis-retinoic acid biosynthetic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0030176 integral component of endoplasmic reticulum membrane
Protein Structure and Domains
PDB ID
InterPro IPR002198 Short-chain dehydrogenase/reductase SDR
IPR002347 Glucose/ribitol dehydrogenase
PFAM PF00106
PRINTS PR00080
PR00081
PIRSF PIRSF000126
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BPW9
PhosphoSite PhosphoSite-
TrEMBL Q4ZG83
UniProt Splice Variant
Entrez Gene 10170
UniGene Hs.608963
RefSeq
HUGO HGNC:16888
OMIM 612131
CCDS
HPRD 09916
IMGT
EMBL AC007556 AC008177 AF240697 AF240698 AF295380 AF343729 AF529286 AF529287 AF529288 AK296625 AY017349 AY359046 BC058883 CH471058
GenPept AAF82747 AAF82748 AAG49422 AAH58883 AAK37528 AAL37037 AAN04008 AAN04009 AAN04010 AAQ89405 AAX88964 BAH12402 EAX11282 EAX11283 EAX11284

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca