InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ATF2

Summary

InnateDB Protein

IDBP-387718.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ATF2

Protein Name

activating transcription factor 2

Synonyms

CRE-BP1; CREB-2; CREB2; HB16; TREB7;

Species

Homo sapiens

Ensembl Protein

ENSP00000407911

InnateDB Gene

IDBG-75609 (ATF2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 387 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Experimentally validated
Total	387 [view]
Protein-Protein	235 [view]
Protein-DNA	152 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001076	RNA polymerase II transcription factor binding transcription factor activity
GO:0001102	RNA polymerase II activating transcription factor binding
GO:0001228	RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0003713	transcription coactivator activity
GO:0004402	histone acetyltransferase activity
GO:0005515	protein binding
GO:0008140	cAMP response element binding protein binding
GO:0019901	protein kinase binding
GO:0035497	cAMP response element binding
GO:0043565	sequence-specific DNA binding
GO:0046872	metal ion binding

Biological Process

GO:0002224	toll-like receptor signaling pathway
GO:0002755	MyD88-dependent toll-like receptor signaling pathway
GO:0002756	MyD88-independent toll-like receptor signaling pathway
GO:0006325	chromatin organization
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0006970	response to osmotic stress
GO:0006974	cellular response to DNA damage stimulus
GO:0016573	histone acetylation
GO:0031573	intra-S DNA damage checkpoint
GO:0034134	toll-like receptor 2 signaling pathway
GO:0034138	toll-like receptor 3 signaling pathway
GO:0034142	toll-like receptor 4 signaling pathway
GO:0034146	toll-like receptor 5 signaling pathway
GO:0034162	toll-like receptor 9 signaling pathway
GO:0034166	toll-like receptor 10 signaling pathway
GO:0035666	TRIF-dependent toll-like receptor signaling pathway
GO:0038123	toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124	toll-like receptor TLR6:TLR2 signaling pathway
GO:0045087	innate immune response (InnateDB)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051090	regulation of sequence-specific DNA binding transcription factor activity
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051403	stress-activated MAPK cascade
GO:1902110	positive regulation of mitochondrial membrane permeability involved in apoptotic process