InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NFE2L2

Summary

InnateDB Protein

IDBP-387756.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NFE2L2

Protein Name

nuclear factor (erythroid-derived 2)-like 2

Synonyms

NRF2;

Species

Homo sapiens

Ensembl Protein

ENSP00000411575

InnateDB Gene

IDBG-75863 (NFE2L2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 89 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Experimentally validated
Total	89 [view]
Protein-Protein	82 [view]
Protein-DNA	6 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001102	RNA polymerase II activating transcription factor binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0019904	protein domain specific binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0010499	proteasomal ubiquitin-independent protein catabolic process
GO:0016567	protein ubiquitination
GO:0036003	positive regulation of transcription from RNA polymerase II promoter in response to stress
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045087	innate immune response (InnateDB)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0070301	cellular response to hydrogen peroxide
GO:0071356	cellular response to tumor necrosis factor
GO:0071499	cellular response to laminar fluid shear stress
GO:1902176	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO:2000352	negative regulation of endothelial cell apoptotic process