Version 5.4
Homo sapiens Protein: RSPO4
Summary
InnateDB Protein IDBP-38793.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RSPO4
Protein Name R-spondin 4
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000217260
InnateDB Gene IDBG-38791 (RSPO4)
Protein Structure
UniProt Annotation
Function Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. {ECO:0000269PubMed:21727895, ECO:0000269PubMed:21909076}.
Subcellular Localization Secreted {ECO:0000250}.
Disease Associations Nail disorder, non-syndromic congenital, 4 (NDNC4) [MIM:206800]: A nail disorder characterized by congenital anonychia or its milder phenotypic variant hyponychia. Anonychia/hyponychia is the absence or severe hypoplasia of all fingernails and toenails without significant bone anomalies. {ECO:0000269PubMed:17041604}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008201 heparin binding
Biological Process
GO:0016055 Wnt signaling pathway
Cellular Component
GO:0005576 extracellular region
Protein Structure and Domains
PDB ID
InterPro IPR000884 Thrombospondin, type 1 repeat
IPR006212 Furin-like repeat
IPR009030 Insulin-like growth factor binding protein, N-terminal
PFAM PF00090
PRINTS
PIRSF
SMART SM00209
SM00261
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q2I0M5
PhosphoSite PhosphoSite-Q2I0M5
TrEMBL
UniProt Splice Variant
Entrez Gene 343637
UniGene Hs.444980
RefSeq NP_001025042
HUGO HGNC:16175
OMIM 610573
CCDS CCDS42846
HPRD
IMGT
EMBL AK122609 AL050325 DQ355152
GenPept ABC75877 CAB65783 CAM28322

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca