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InnateDB Protein
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IDBP-388400.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SETDB1
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Protein Name
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SET domain, bifurcated 1
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Synonyms
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ESET; H3-K9-HMTase4; KG1T; KMT1E; TDRD21;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000407831
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InnateDB Gene
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IDBG-102210 (SETDB1)
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Protein Structure
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| Function |
Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys-9' trimethylation is coordinated with DNA methylation. Probably forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1. SETDB1 is targeted to histone H3 by TRIM28/TIF1B, a factor recruited by KRAB zinc-finger proteins. {ECO:0000269PubMed:12869583, ECO:0000269PubMed:14536086, ECO:0000269PubMed:15327775, ECO:0000269PubMed:17952062}.
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| Subcellular Localization |
Nucleus. Chromosome. Note=Associated with non-pericentromeric regions of chromatin. Excluded from nucleoli and islands of condensed chromatin.
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| Disease Associations |
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| Tissue Specificity |
Widely expressed. High expression in testis.
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| Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 165 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
| Experimentally validated |
| Total |
165
[view]
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| Protein-Protein |
164
[view]
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| Protein-DNA |
1
[view]
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| Protein-RNA |
0
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| DNA-DNA |
0
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| RNA-RNA |
0
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| DNA-RNA |
0
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| Predicted by orthology |
| Total |
10 [view]
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| PDB ID |
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| InterPro |
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| PFAM |
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| PRINTS |
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| PIRSF |
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| SMART |
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| TIGRFAMs |
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| Modification |
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| SwissProt |
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| PhosphoSite |
PhosphoSite-Q15047
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| TrEMBL |
X6RHV1
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| UniProt Splice Variant |
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| Entrez Gene |
9869
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| UniGene |
Hs.643565
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| RefSeq |
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| HUGO |
HGNC:10761
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| OMIM |
604396
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| CCDS |
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| HPRD |
06828
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| IMGT |
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| EMBL |
AL590133
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| GenPept |
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Version 5.4