Version 5.4
Homo sapiens Protein: CHTF8
Summary
InnateDB Protein IDBP-38864.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CHTF8
Protein Name CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000305687
InnateDB Gene IDBG-38862 (CHTF8)
Protein Structure
UniProt Annotation
Function Potential tumor suppressor. Inhibits prostate tumor cell growth, when overexpressed. {ECO:0000269PubMed:12477976}.
Subcellular Localization Nucleus {ECO:0000269PubMed:12477976}.
Disease Associations
Tissue Specificity Ubiquitously expressed, with abundant expression in kidney, skeletal muscle, testis, liver, ovary, and heart and moderate expression in prostate. Expression is significantly reduced in renal and prostate tumors. No differential expression in breast cancer cells, between lobular carcinoma and normal lobules. {ECO:0000269PubMed:12477976, ECO:0000269PubMed:18213475}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P0CG12
PhosphoSite PhosphoSite-P0CG12
TrEMBL L0R4W3
UniProt Splice Variant
Entrez Gene 54921
UniGene Hs.85962
RefSeq
HUGO HGNC:24353
OMIM 613202
CCDS
HPRD 16797
IMGT
EMBL AC009027 AL833902 CH471092 HF547997
GenPept CAD38758 CCO13708 EAW83250

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca