InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FN1

Summary

InnateDB Protein

IDBP-388795.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FN1

Protein Name

fibronectin 1

Synonyms

CIG; ED-B; FINC; FN; FNZ; GFND; GFND2; LETS; MSF;

Species

Homo sapiens

Ensembl Protein

ENSP00000399538

InnateDB Gene

IDBG-80237 (FN1)

Protein Structure

UniProt Annotation

Function

Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts.Anastellin binds fibronectin and induces fibril formation. This fibronectin polymer, named superfibronectin, exhibits enhanced adhesive properties. Both anastellin and superfibronectin inhibit tumor growth, angiogenesis and metastasis. Anastellin activates p38 MAPK and inhibits lysophospholipid signaling.

Subcellular Localization

Secreted, extracellular space, extracellular matrix.

Disease Associations

Glomerulopathy with fibronectin deposits 2 (GFND2) [MIM:601894]: Genetically heterogeneous autosomal dominant disorder characterized clinically by proteinuria, microscopic hematuria, and hypertension that leads to end-stage renal failure in the second to fifth decade of life. {ECO:0000269PubMed:18268355}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Plasma FN (soluble dimeric form) is secreted by hepatocytes. Cellular FN (dimeric or cross-linked multimeric forms), made by fibroblasts, epithelial and other cell types, is deposited as fibrils in the extracellular matrix. Ugl-Y1, Ugl-Y2 and Ugl-Y3 are found in urine. {ECO:0000269PubMed:17614963, ECO:0000269PubMed:3584091}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 758 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	758 [view]
Protein-Protein	757 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0005178	integrin binding
GO:0005515	protein binding
GO:0005518	collagen binding
GO:0008201	heparin binding

Biological Process

GO:0001525	angiogenesis
GO:0002576	platelet degranulation
GO:0006953	acute-phase response
GO:0007155	cell adhesion
GO:0007596	blood coagulation
GO:0008360	regulation of cell shape
GO:0009611	response to wounding
GO:0018149	peptide cross-linking
GO:0022617	extracellular matrix disassembly
GO:0030168	platelet activation
GO:0030198	extracellular matrix organization
GO:0034446	substrate adhesion-dependent cell spreading
GO:0050900	leukocyte migration

Cellular Component

GO:0005576	extracellular region
GO:0005577	fibrinogen complex
GO:0005615	extracellular space
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
GO:0031012	extracellular matrix
GO:0031093	platelet alpha granule lumen
GO:0070062	extracellular vesicular exosome
GO:0072562	blood microparticle