InnateDB Protein
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IDBP-389134.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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AP1S3
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Protein Name
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adaptor-related protein complex 1, sigma 3 subunit
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000388738
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InnateDB Gene
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IDBG-82268 (AP1S3)
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Protein Structure
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Function |
Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.
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Subcellular Localization |
Golgi apparatus. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, clathrin-coated pit. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.
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Disease Associations |
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Tissue Specificity |
Widely expressed.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
6
[view]
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Protein-Protein |
6
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0008565
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protein transporter activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR011012
Longin-like domain
IPR016635
Adaptor protein complex, sigma subunit
IPR022775
AP complex, mu/sigma subunit
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PFAM |
PF01217
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PRINTS |
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PIRSF |
PIRSF015588
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q96PC3
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PhosphoSite |
PhosphoSite-Q96PC3
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TrEMBL |
Q53R44
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UniProt Splice Variant |
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Entrez Gene |
130340
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UniGene |
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RefSeq |
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HUGO |
HGNC:18971
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OMIM |
615781
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CCDS |
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HPRD |
16495
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IMGT |
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EMBL |
AC012512
AC093884
AF393369
AK299026
BC009606
BC021898
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GenPept |
AAH09606
AAH21898
AAL09586
AAY24166
BAG61103
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