Version 5.4
Homo sapiens Protein: BLOC1S1
Summary
InnateDB Protein IDBP-38914.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BLOC1S1
Protein Name biogenesis of lysosomal organelles complex-1, subunit 1
Synonyms BLOS1; GCN5L1; MICoA; RT14;
Species Homo sapiens
Ensembl Protein ENSP00000257899
InnateDB Gene IDBG-38912 (BLOC1S1)
Protein Structure
UniProt Annotation
Function Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May negatively regulate aerobic respiration through mitochondrial protein lysine-acetylation. May counteract the action of the deacetylase SIRT3 by acetylating and regulating proteins of the mitochondrial respiratory chain including ATP5A1 and NDUFA9. {ECO:0000269PubMed:17182842, ECO:0000269PubMed:22309213}.
Subcellular Localization Mitochondrion intermembrane space {ECO:0000269PubMed:22309213}. Mitochondrion matrix {ECO:0000269PubMed:22309213}. Cytoplasm, cytosol {ECO:0000269PubMed:22309213}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
Experimentally validated
Total 21 [view]
Protein-Protein 20 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006892 post-Golgi vesicle-mediated transport
GO:0008089 anterograde axon cargo transport
GO:0009060 aerobic respiration
GO:0018394 peptidyl-lysine acetylation
GO:0031175 neuron projection development
GO:0032438 melanosome organization
GO:0048490 anterograde synaptic vesicle transport
GO:0060155 platelet dense granule organization
GO:0061024 membrane organization
Cellular Component
GO:0005615 extracellular space
GO:0005758 mitochondrial intermembrane space
GO:0005759 mitochondrial matrix
GO:0005765 lysosomal membrane
GO:0005829 cytosol
GO:0031083 BLOC-1 complex
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR009395 GCN5-like 1
PFAM PF06320
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P78537
PhosphoSite PhosphoSite-P78537
TrEMBL F8W099
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq
HUGO
OMIM 601444
CCDS
HPRD 03263
IMGT
EMBL AC009779 BC130640 BC132795 D64007 S82447
GenPept AAB37682 AAI30641 AAI32796 BAA10887

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca