Version 5.4
Homo sapiens Protein: TOR1AIP1
Summary
InnateDB Protein IDBP-389776.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TOR1AIP1
Protein Name torsin A interacting protein 1
Synonyms LAP1; LAP1B;
Species Homo sapiens
Ensembl Protein ENSP00000393292
InnateDB Gene IDBG-105140 (TOR1AIP1)
Protein Structure
UniProt Annotation
Function Required for nuclear membrane integrity. Induces TOR1A and TOR1B ATPase activity and is required for their location on the nuclear membrane. Binds to A- and B-type lamins. Possible role in membrane attachment and assembly of the nuclear lamina. {ECO:0000269PubMed:23569223}.
Subcellular Localization Nucleus inner membrane {ECO:0000269PubMed:12061773, ECO:0000269PubMed:24275647}; Single-pass membrane protein {ECO:0000269PubMed:12061773, ECO:0000269PubMed:24275647}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 27 [view]
Protein-Protein 26 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Protein Structure and Domains
PDB ID
InterPro IPR008662 Lamina-associated polypeptide 1C
PFAM PF05609
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-Q5JTV8
TrEMBL
UniProt Splice Variant
Entrez Gene 26092
UniGene Hs.496459
RefSeq
HUGO HGNC:29456
OMIM 614512
CCDS
HPRD 13958
IMGT
EMBL
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca