InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LAX1

Summary

InnateDB Protein

IDBP-389915.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LAX1

Protein Name

lymphocyte transmembrane adaptor 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000406970

InnateDB Gene

IDBG-105972 (LAX1)

Protein Structure

UniProt Annotation

Function

Negatively regulates TCR (T-cell antigen receptor)- mediated signaling in T-cells and BCR (B-cell antigen receptor)- mediated signaling in B-cells. {ECO:0000269PubMed:12359715}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:12359715}; Single-pass type III membrane protein {ECO:0000269PubMed:12359715}.

Disease Associations

Tissue Specificity

Expressed in spleen, thymus, and peripheral blood leukocytes. Expressed in several B-, T-, NK and monocyte cell lines. {ECO:0000269PubMed:12359715}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0042169	SH2 domain binding

Biological Process

GO:0000188	inactivation of MAPK activity
GO:0006955	immune response
GO:0035556	intracellular signal transduction
GO:0042113	B cell activation
GO:0046649	lymphocyte activation
GO:0048305	immunoglobulin secretion
GO:0050851	antigen receptor-mediated signaling pathway
GO:0050868	negative regulation of T cell activation