InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IL10

Summary

InnateDB Protein

IDBP-389967.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IL10

Protein Name

interleukin 10

Synonyms

CSIF; GVHDS; IL-10; IL10A; TGIF;

Species

Homo sapiens

Ensembl Protein

ENSP00000412237

InnateDB Gene

IDBG-106270 (IL10)

Protein Structure

UniProt Annotation

Function

Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Produced by a variety of cell lines, including T-cells, macrophages, mast cells and other cell types.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	23 [view]
Protein-Protein	11 [view]
Protein-DNA	11 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	1 [view]
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005141	interleukin-10 receptor binding
GO:0008083	growth factor activity

Biological Process

GO:0001818	negative regulation of cytokine production
GO:0002237	response to molecule of bacterial origin
GO:0002740	negative regulation of cytokine secretion involved in immune response
GO:0002875	negative regulation of chronic inflammatory response to antigenic stimulus
GO:0002904	positive regulation of B cell apoptotic process
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0007253	cytoplasmic sequestering of NF-kappaB
GO:0007267	cell-cell signaling
GO:0007568	aging
GO:0010033	response to organic substance
GO:0010468	regulation of gene expression
GO:0014823	response to activity
GO:0014854	response to inactivity
GO:0030097	hemopoiesis
GO:0030183	B cell differentiation
GO:0030595	leukocyte chemotaxis
GO:0030886	negative regulation of myeloid dendritic cell activation
GO:0030889	negative regulation of B cell proliferation
GO:0032496	response to lipopolysaccharide
GO:0032689	negative regulation of interferon-gamma production
GO:0032695	negative regulation of interleukin-12 production
GO:0032715	negative regulation of interleukin-6 production
GO:0032720	negative regulation of tumor necrosis factor production
GO:0032800	receptor biosynthetic process
GO:0032868	response to insulin
GO:0034465	response to carbon monoxide
GO:0042092	type 2 immune response
GO:0042100	B cell proliferation
GO:0042130	negative regulation of T cell proliferation
GO:0042493	response to drug
GO:0042536	negative regulation of tumor necrosis factor biosynthetic process
GO:0042742	defense response to bacterium
GO:0043066	negative regulation of apoptotic process
GO:0044130	negative regulation of growth of symbiont in host
GO:0045019	negative regulation of nitric oxide biosynthetic process
GO:0045087	innate immune response (InnateDB)
GO:0045191	regulation of isotype switching
GO:0045347	negative regulation of MHC class II biosynthetic process
GO:0045348	positive regulation of MHC class II biosynthetic process
GO:0045355	negative regulation of interferon-alpha biosynthetic process
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0050715	positive regulation of cytokine secretion
GO:0050728	negative regulation of inflammatory response
GO:0051045	negative regulation of membrane protein ectodomain proteolysis
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051384	response to glucocorticoid
GO:0051930	regulation of sensory perception of pain
GO:0060670	branching involved in labyrinthine layer morphogenesis
GO:0071222	cellular response to lipopolysaccharide
GO:0071392	cellular response to estradiol stimulus