Homo sapiens Protein: IL10
InnateDB Protein IDBP-389967.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL10
Protein Name interleukin 10
Synonyms CSIF; GVHDS; IL-10; IL10A; TGIF;
Species Homo sapiens
Ensembl Protein ENSP00000412237
InnateDB Gene IDBG-106270 (IL10)
Protein Structure
UniProt Annotation
Function Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity Produced by a variety of cell lines, including T-cells, macrophages, mast cells and other cell types.
Number of Interactions This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Experimentally validated
Total 23 [view]
Protein-Protein 11 [view]
Protein-DNA 11 [view]
Protein-RNA 0
RNA-RNA 1 [view]
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005141 interleukin-10 receptor binding
GO:0008083 growth factor activity
Biological Process
GO:0001818 negative regulation of cytokine production
GO:0002237 response to molecule of bacterial origin
GO:0002740 negative regulation of cytokine secretion involved in immune response
GO:0002875 negative regulation of chronic inflammatory response to antigenic stimulus
GO:0002904 positive regulation of B cell apoptotic process
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007253 cytoplasmic sequestering of NF-kappaB
GO:0007267 cell-cell signaling
GO:0007568 aging
GO:0010033 response to organic substance
GO:0010468 regulation of gene expression
GO:0014823 response to activity
GO:0014854 response to inactivity
GO:0030097 hemopoiesis
GO:0030183 B cell differentiation
GO:0030595 leukocyte chemotaxis
GO:0030886 negative regulation of myeloid dendritic cell activation
GO:0030889 negative regulation of B cell proliferation
GO:0032496 response to lipopolysaccharide
GO:0032689 negative regulation of interferon-gamma production
GO:0032695 negative regulation of interleukin-12 production
GO:0032715 negative regulation of interleukin-6 production
GO:0032720 negative regulation of tumor necrosis factor production
GO:0032800 receptor biosynthetic process
GO:0032868 response to insulin
GO:0034465 response to carbon monoxide
GO:0042092 type 2 immune response
GO:0042100 B cell proliferation
GO:0042130 negative regulation of T cell proliferation
GO:0042493 response to drug
GO:0042536 negative regulation of tumor necrosis factor biosynthetic process
GO:0042742 defense response to bacterium
GO:0043066 negative regulation of apoptotic process
GO:0044130 negative regulation of growth of symbiont in host
GO:0045019 negative regulation of nitric oxide biosynthetic process
GO:0045087 innate immune response (InnateDB)
GO:0045191 regulation of isotype switching
GO:0045347 negative regulation of MHC class II biosynthetic process
GO:0045348 positive regulation of MHC class II biosynthetic process
GO:0045355 negative regulation of interferon-alpha biosynthetic process
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0050715 positive regulation of cytokine secretion
GO:0050728 negative regulation of inflammatory response
GO:0051045 negative regulation of membrane protein ectodomain proteolysis
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051384 response to glucocorticoid
GO:0051930 regulation of sensory perception of pain
GO:0060670 branching involved in labyrinthine layer morphogenesis
GO:0071222 cellular response to lipopolysaccharide
GO:0071392 cellular response to estradiol stimulus
Cellular Component
GO:0005615 extracellular space
Protein Structure and Domains
InterPro IPR000098 Interleukin-10
IPR009079 Four-helical cytokine-like, core
IPR020443 Interleukin-10/19/20/24/26 family
PFAM PF00726
Post-translational Modifications
SwissProt P22301
PhosphoSite PhosphoSite-
UniProt Splice Variant
Entrez Gene 3586
UniGene Hs.193717
RefSeq NP_000563
OMIM 124092
HPRD 00495
EMBL AF043333 AF418271 AY029171 BC104252 BC104253 CH471100 CR541993 DQ217938 GQ405199 M57627 U16720 X78437
GenPept AAA63207 AAA80104 AAC03534 AAI04253 AAI04254 AAK38162 AAL06594 ABB01008 ACV30066 CAA55201 CAG46790 EAW93524