InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TNNC1

Summary

InnateDB Protein

IDBP-38999.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TNNC1

Protein Name

troponin C type 1 (slow)

Synonyms

CMD1Z; CMH13; TN-C; TNC; TNNC;

Species

Homo sapiens

Ensembl Protein

ENSP00000232975

InnateDB Gene

IDBG-38997 (TNNC1)

Protein Structure

UniProt Annotation

Function

Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.

Subcellular Localization

Disease Associations

Cardiomyopathy, dilated 1Z (CMD1Z) [MIM:611879]: A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. {ECO:0000269PubMed:15542288}. Note=The disease is caused by mutations affecting the gene represented in this entry.Cardiomyopathy, familial hypertrophic 13 (CMH13) [MIM:613243]: A hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. {ECO:0000269PubMed:11385718, ECO:0000269PubMed:18572189}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.

Experimentally validated
Total	16 [view]
Protein-Protein	16 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0031013	troponin I binding
GO:0031014	troponin T binding
GO:0042803	protein homodimerization activity
GO:0048306	calcium-dependent protein binding
GO:0051015	actin filament binding

Biological Process

GO:0002086	diaphragm contraction
GO:0006937	regulation of muscle contraction
GO:0010038	response to metal ion
GO:0030049	muscle filament sliding
GO:0032972	regulation of muscle filament sliding speed
GO:0043462	regulation of ATPase activity
GO:0055010	ventricular cardiac muscle tissue morphogenesis
GO:0060048	cardiac muscle contraction