Version 5.4
Homo sapiens Protein: PROX1
Summary
InnateDB Protein IDBP-390014.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PROX1
Protein Name prospero homeobox 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000400694
InnateDB Gene IDBG-106631 (PROX1)
Protein Structure
UniProt Annotation
Function May play a fundamental role in early development of CNS. May regulate gene expression and development of postmitotic undifferentiated young neurons (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000305}.
Disease Associations
Tissue Specificity Most actively expressed in the developing lens. Detected also in embryonic brain, lung, liver and kidney. In adult, it is more abundant in heart and liver than in brain, skeletal muscle, kidney and pancreas.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 26 [view]
Protein-Protein 24 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0016922 ligand-dependent nuclear receptor binding
GO:0044212 transcription regulatory region DNA binding
GO:0050692 DBD domain binding
GO:0050693 LBD domain binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001822 kidney development
GO:0001889 liver development
GO:0001938 positive regulation of endothelial cell proliferation
GO:0001946 lymphangiogenesis
GO:0002088 lens development in camera-type eye
GO:0007420 brain development
GO:0008284 positive regulation of cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0010468 regulation of gene expression
GO:0010595 positive regulation of endothelial cell migration
GO:0021516 dorsal spinal cord development
GO:0021542 dentate gyrus development
GO:0021707 cerebellar granule cell differentiation
GO:0021915 neural tube development
GO:0030240 skeletal muscle thin filament assembly
GO:0030324 lung development
GO:0030910 olfactory placode formation
GO:0031016 pancreas development
GO:0043049 otic placode formation
GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045071 negative regulation of viral genome replication
GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045787 positive regulation of cell cycle
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046619 optic placode formation involved in camera-type eye formation
GO:0048845 venous blood vessel morphogenesis
GO:0055005 ventricular cardiac myofibril assembly
GO:0055009 atrial cardiac muscle tissue morphogenesis
GO:0055010 ventricular cardiac muscle tissue morphogenesis
GO:0060042 retina morphogenesis in camera-type eye
GO:0060059 embryonic retina morphogenesis in camera-type eye
GO:0060214 endocardium formation
GO:0060298 positive regulation of sarcomere organization
GO:0060412 ventricular septum morphogenesis
GO:0060414 aorta smooth muscle tissue morphogenesis
GO:0060421 positive regulation of heart growth
GO:0060836 lymphatic endothelial cell differentiation
GO:0060849 regulation of transcription involved in lymphatic endothelial cell fate commitment
GO:0070309 lens fiber cell morphogenesis
GO:0070365 hepatocyte differentiation
GO:0070858 negative regulation of bile acid biosynthetic process
GO:0097150 neuronal stem cell maintenance
GO:2000179 positive regulation of neural precursor cell proliferation
GO:2000979 positive regulation of forebrain neuron differentiation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR009057 Homeodomain-like
IPR023082 Homeo-prospero domain
PFAM PF05044
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q92786
PhosphoSite PhosphoSite-Q92786
TrEMBL U3KPY6
UniProt Splice Variant
Entrez Gene 5629
UniGene Hs.743536
RefSeq NP_002754
HUGO HGNC:9459
OMIM 601546
CCDS CCDS31021
HPRD 03330
IMGT
EMBL AC011700 AK290176 AK298182 AL606537 BC024201 CH471100 U44060
GenPept AAC50656 AAH24201 BAF82865 BAG60453 CAI15309 EAW93360

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca