Version 5.4
Homo sapiens Protein: ITPKB
Summary
InnateDB Protein IDBP-390084.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ITPKB
Protein Name inositol-trisphosphate 3-kinase B
Synonyms IP3-3KB; IP3K; IP3K-B; IP3KB; PIG37;
Species Homo sapiens
Ensembl Protein ENSP00000411152
InnateDB Gene IDBG-107048 (ITPKB)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity
Biological Process
GO:0000165 MAPK cascade
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0030217 T cell differentiation
GO:0043647 inositol phosphate metabolic process
GO:0044281 small molecule metabolic process
GO:0045059 positive thymic T cell selection
GO:0045061 thymic T cell selection
GO:0046579 positive regulation of Ras protein signal transduction
GO:0046638 positive regulation of alpha-beta T cell differentiation
Cellular Component
GO:0005829 cytosol
Protein Structure and Domains
PDB ID
InterPro IPR005522 Inositol polyphosphate kinase
PFAM PF03770
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P27987
PhosphoSite PhosphoSite-P27987
TrEMBL
UniProt Splice Variant
Entrez Gene 3707
UniGene Hs.743604
RefSeq NP_002212
HUGO HGNC:6179
OMIM 147522
CCDS CCDS1555
HPRD 00942
IMGT
EMBL AJ242780 AL365444 BC015009 X57206 Y18024
GenPept AAH15009 CAA40491 CAB65055 CAC40650 CAH70187 CAH70188

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca