InnateDB Protein
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IDBP-390158.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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GNG4
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Protein Name
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guanine nucleotide binding protein (G protein), gamma 4
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000398629
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InnateDB Gene
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IDBG-107558 (GNG4)
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Protein Structure
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Function |
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction.
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Subcellular Localization |
Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
Brain, kidney, pancreas, skeletal muscle and faintly in cardiac muscle.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
10
[view]
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Protein-Protein |
10
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
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Biological Process |
GO:0006112
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energy reserve metabolic process
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GO:0007186
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G-protein coupled receptor signaling pathway
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GO:0007268
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synaptic transmission
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GO:0008277
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regulation of G-protein coupled receptor protein signaling pathway
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GO:0030308
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negative regulation of cell growth
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GO:0044281
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small molecule metabolic process
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GO:0071377
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cellular response to glucagon stimulus
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Cellular Component |
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PDB ID |
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InterPro |
IPR001770
G-protein, gamma subunit
IPR015898
G-protein gamma-like domain
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PFAM |
PF00631
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PRINTS |
PR00321
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PIRSF |
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SMART |
SM00224
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TIGRFAMs |
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Modification |
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SwissProt |
P50150
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PhosphoSite |
PhosphoSite-
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TrEMBL |
B1APZ0
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UniProt Splice Variant |
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Entrez Gene |
2786
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UniGene |
Hs.159711
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RefSeq |
NP_001092191
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HUGO |
HGNC:4407
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OMIM |
604388
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CCDS |
CCDS1607
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HPRD |
11978
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IMGT |
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EMBL |
AF493872
AK311781
BC022485
CH471098
U31382
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GenPept |
AAC50204
AAH22485
AAM12586
BAG34724
EAW70030
EAW70031
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