InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: STAB1

Summary

InnateDB Protein

IDBP-39111.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

STAB1

Protein Name

stabilin 1

Synonyms

CLEVER-1; FEEL-1; FELE-1; FEX1; STAB-1;

Species

Homo sapiens

Ensembl Protein

ENSP00000312946

InnateDB Gene

IDBG-39109 (STAB1)

Protein Structure

UniProt Annotation

Function

Acts as a scavenger receptor for acetylated low density lipoprotein. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. When inhibited in endothelial tube formation assays, there is a marked decrease in cell-cell interactions, suggesting a role in angiogenesis. Involved in the delivery of newly synthesized CHID1/SI-CLP from the biosynthetic compartment to the endosomal/lysosomal system. {ECO:0000269PubMed:12077138, ECO:0000269PubMed:16357325}.

Subcellular Localization

Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

High levels found in spleen, lymph node, liver and placenta. Also expressed in endothelial cells. {ECO:0000269PubMed:11829752, ECO:0000269PubMed:12077138}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005041	low-density lipoprotein receptor activity
GO:0005044	scavenger receptor activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005540	hyaluronic acid binding
GO:0015035	protein disulfide oxidoreductase activity
GO:0030169	low-density lipoprotein particle binding

Biological Process

GO:0006898	receptor-mediated endocytosis
GO:0006954	inflammatory response
GO:0007155	cell adhesion
GO:0007267	cell-cell signaling
GO:0016525	negative regulation of angiogenesis
GO:0042742	defense response to bacterium
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0030666	endocytic vesicle membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000538 Link
IPR000742 Epidermal growth factor-like domain
IPR000782 FAS1 domain
IPR001881 EGF-like calcium-binding domain
IPR002049 EGF-like, laminin
IPR016187 C-type lectin fold

PFAM

PF00193
PF00008
PF02469
PF07645
PF00053

PRINTS

PR01265

PIRSF

SMART

SM00445
SM00181
SM00554
SM00179
SM00180

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt