InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ADAP2

Summary

InnateDB Protein

IDBP-39333.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ADAP2

Protein Name

ArfGAP with dual PH domains 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000329468

InnateDB Gene

IDBG-39331 (ADAP2)

Protein Structure

UniProt Annotation

Function

GTPase-activating protein for the ADP ribosylation factor family (Potential). Binds phosphatidylinositol 3,4,5- trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4). Possesses a stoichiometry of two binding sites for InsP4 with identical affinity. {ECO:0000269PubMed:14690521, ECO:0000305}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:14690521}. Cell membrane {ECO:0000269PubMed:14690521}. Note=Constitutively associated with the plasma membrane. Excluded from the nucleus.

Disease Associations

Tissue Specificity

Highly expressed in placenta, spleen, kidney, skeletal muscle and adrenal gland. Weakly expressed in thyroid, liver, heart, lung, small intestine, peripheral blood leukocytes. Not detected in spinal cord, brain, stomach, trachea, colon, lymph node and bone marrow. {ECO:0000269PubMed:14690521}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding
GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding
GO:0008060	ARF GTPase activator activity
GO:0008270	zinc ion binding
GO:0030674	protein binding, bridging
GO:0043325	phosphatidylinositol-3,4-bisphosphate binding
GO:0043533	inositol 1,3,4,5 tetrakisphosphate binding