InnateDB Protein
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IDBP-39501.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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FKBP1A
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Protein Name
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FK506 binding protein 1A, 12kDa
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Synonyms
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FKBP-12; FKBP-1A; FKBP1; FKBP12; PKC12; PKCI2; PPIASE;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000371138
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InnateDB Gene
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IDBG-39495 (FKBP1A)
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Protein Structure
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Function |
Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruites SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. {ECO:0000269PubMed:16720724, ECO:0000269PubMed:9233797}.
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Subcellular Localization |
Cytoplasm.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001179
Peptidyl-prolyl cis-trans isomerase, FKBP-type, domain
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PFAM |
PF00254
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P62942
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PhosphoSite |
PhosphoSite-P62942
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TrEMBL |
Q9UH88
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UniProt Splice Variant |
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Entrez Gene |
2280
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UniGene |
Hs.471933
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RefSeq |
NP_463460
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HUGO |
HGNC:3711
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OMIM |
186945
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CCDS |
CCDS13014
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HPRD |
01741
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IMGT |
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EMBL |
AF205192
AL109658
AL136531
BC001925
BC005147
BC119732
BC119733
BT007066
CH471133
CR407613
CR542168
M34539
M80199
M92422
M92423
M93060
X52220
X55741
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GenPept |
AAA35844
AAA58472
AAA58476
AAF17608
AAH01925
AAH05147
AAI19733
AAI19734
AAP35729
CAA36462
CAA39272
CAG28541
CAG46965
CAH72382
CAI22728
EAX10633
EAX10634
EAX10635
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