InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ABCE1

Summary

InnateDB Protein

IDBP-39793.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ABCE1

Protein Name

ATP-binding cassette, sub-family E (OABP), member 1

Synonyms

ABC38; OABP; RLI; RNASEL1; RNASELI; RNS4I;

Species

Homo sapiens

Ensembl Protein

ENSP00000296577

InnateDB Gene

IDBG-39791 (ABCE1)

Protein Structure

UniProt Annotation

Function

Antagonizes the binding of 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) by RNase L through direct interaction with RNase L and therefore inhibits its endoribonuclease activity. May play a central role in the regulation of mRNA turnover. Antagonizes the anti-viral effect of the interferon-regulated 2-5A/RNase L pathway. May act as a chaperone for post-translational events during HIV-1 capsid assembly. {ECO:0000269PubMed:11585831, ECO:0000269PubMed:9660177, ECO:0000269PubMed:9847332}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:11585831}. Mitochondrion {ECO:0000269PubMed:11585831}. Note=Localized to clusters of virus formation at the plasma membrane.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.

Experimentally validated
Total	28 [view]
Protein-Protein	24 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005524	ATP binding
GO:0008428	ribonuclease inhibitor activity
GO:0016887	ATPase activity
GO:0051536	iron-sulfur cluster binding

Biological Process

GO:0006200	ATP catabolic process
GO:0006401	RNA catabolic process
GO:0009615	response to virus
GO:0016032	viral process
GO:0043086	negative regulation of catalytic activity

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001450 4Fe-4S binding domain
IPR003439 ABC transporter-like
IPR003593 AAA+ ATPase domain
IPR007209 RNase L inhibitor RLI, possible metal-binding domain
IPR013283 ABC transporter, ABCE
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM